When a new witness steps forward, Lilly and the team are prompted to re-open the 1984 shooting of a respected and beloved ER doctor who had a secret he had been hiding from his family.
- Kathryn Morris as Lilly Rush
- Danny Pino as Scotty Valens
- John Finn as John Stillman
- Jeremy Ratchford as Nick Vera
- Thom Barry as Will Jeffries
- Tracie Thoms as Kat Miller
- V.J. Foster as Cyrus Tisdale
- Stacy Haiduk as Anne Bowen (1984)
- Eamonn Roche as Dr. Seth Garvey (1984)
- Mark Tymchyshyn as Dr. Seth Garvey (2006)
- Emmanuel Xuereb as Dr. Grant Bowen (1984)
- Brielle Bourgeois as Veronica Miller
- Kevin Brief as Sidney Graber
- Jason Chanos as Dr. Jason Bowen (2006)
- Christopher Goodson as Bob
- Alice Lo as Mrs. Lee (2006)
- Brent Schindele as Waiter (1984)
- Licia Shearer as Edwina Davis
- Unknown actress as Sarah Graber
- Kayla Odoms' case box is visible when the detectives are examining Grant Bowen's case box in the case room.
- Emmanual Xuereb (Grant Bowen) is the brother of actor Salvatore Xuereb, who co-starred with Kathryn Morris in the TV show Pensacola: Wings of Gold.
- Bonnie Tyler "Holding Out For A Hero"
- Eddie Money "Think I'm In Love"
- Billy Idol "Rebel Yell"
- The Cars "Drive"
- Depeche Mode "Blasphemous Rumors"
- Peter Gabriel "Mercy Street"
- Closing Song: Asia "Only Time Will Tell"